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KMID : 0379520080240030183
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한국독성학회지
2008 Volume.24 No. 3 p.183 ~ p.188
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Strain-dependent Differences of Locomotor Activity and Hippocampus-dependent Learning and Memory in Mice
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Kim Joong-Sun
Kim Seong-Ho
Kim Jong-Choon
Lee Yong-Duk
Shin Tae-Kyun
Kim Seung-Joon
Moon Chang-Jong
Yang Mi-Young
Son Yeong-Hoon
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Abstract
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The behavioral phenotypes of out-bred ICR mice were compared with those of in-bred C57BL/6 and BALB/c mice. In particular, this study examined the locomotor activity and two forms of hippocampus-dependent learning paradigms, passive avoidance and object recognition memory. The basal open-field activity of the ICR strain was greater than that of the C57BL/6 and BALB/c strains. In the passive avoidance task, all the mice showed a significant increase in the cross-over latency when tested 24 hours after training. The strength of memory retention in the ICR mice was relatively weak and measurable, as indicated by the shorter cross-over latency than the C57BL/6 and BALB/c mice. In the object recognition memory test, all strains had a significant preference for the novel object during testing. The index for the preference of a novel object was lower for the ICR and BALB/c mice. Nevertheless, the variance and the standard deviation in these strains were comparable. Overall, these results confirm the strain differences on locomotor activity and hippocampus-dependent learning and memory in mice.
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KEYWORD
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Behavioral difference, Mouse strain, Locomotor activity, Passive avoidance, Object recognition memory
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